Background
Daniel S. Reynolds earned his PhD in biomedical engineering from Boston University and completed postdoctoral training at Harvard University where his research focused on novel biomaterials and bioprinting technologies for disease modeling and therapeutic applications. He also gained extensive experience in technology development through an intensive fellowship with the Harvard Office of Technology Development, participation in several Boston-based technology development programs, and as a recipient of the Harvard Blavatnik Biomedical Accelerator Award.
The Biofabrication and Cancer Engineering Lab integrates biomaterials, mechanical design and tissue engineering principles to develop bioprinted tissues that replicate the complexity of the native in vivo microenvironment. Researchers apply these approaches to the emerging field of cancer engineering with a particular focus on bioprinted tumor models. These models serve as versatile platforms to explore cancer immunobiology, evaluate cell-based immunotherapies, test combinatorial treatment strategies and advance efforts in precision medicine.
Other areas of interest in the Biofabrication and Cancer Engineering Lab include biomaterials design, engineered vascularized tissues and mechanobiology.
Significant Publications
- P.P. Stankey, S. Uzel, K. Kroll, A. Ainscough, D.S. Reynolds, A. Elamine, B. Fichtenkort, J.A. Lewis. Embedding biomimetic vascular networks via coaxial sacrificial writing into functional tissue. Adv. Mater. 36:36 (2024).
- D.S. Reynolds, I. de Lazaro, M. Blache, Y. Liu, N. Jeffreys, R. Doolittle, E. Grandidier, J. Olszewski, M. Dacus, D.J. Mooney, J.A. Lewis. Microporogen-structured collagen matrices for embedded bioprinting of tumor models for immuno-oncology. Adv. Mater. 35:33 (2023).
- M.B. Nagarajan, A. Ainscough, D.S Reynolds, S.G.M. Uzel, J.W. Bjork, B.A. Baker, A.K. McNulty, S.L. Woulfe, J.A. Lewis. Biomimetic human skin model patterned with rete ridges. Biofabrication. 16:1 (2023).
- D.S. Reynolds, K.M. Bougher, J.H. Letendre, S.F. Fitzgerald, U.O. Gisladottir, M.W. Grinstaff, M.H. Zaman. Mechanical confinement via a PEG/Collagen interpenetrating network inhibits behavior characteristic of malignant cells in the triple negative breast cancer cell line MDA.MB.231. Acta Biomater. 77 (2018).
- D.S. Reynolds*, K.M. Tevis*, W.A. Blessing, Y.L. Colson, M.H. Zaman, M.W. Grinstaff. Breast cancer spheroids reveal a differential cancer stem cell response to chemotherapeutic treatment. Sci. Rep. 7:1 (2017). *co-first author
- D.S. Reynolds*, F. Spill*, R.D. Kamm, M.H. Zaman. Impact of the physical microenvironment on tumor progression and metastasis. Curr. Opin. Biotechnol. 40 (2016). *co-first author
Patents
- P.P. Stankey, S.G.M Uzel, D.S. Reynolds, J.A. Lewis. 鈥淢ethods for embedded 3D printing of functional constructs for biological, robotic or other applications鈥. U.S. Provisional Patent Application No. 63/539,871.
- D.S. Reynolds, S. Uzel, R. Doolittle, L. Perry, J.A. Lewis. 鈥淪uturable cuff, method of integrating a tissue construct with a host organ or vasculature, and method of making a suturable cuff鈥. U.S. Patent Application No. 63/313,085.
- D.S. Reynolds, J.A. Lewis. 鈥淧rintable bioink and method of printing tissue/organ model or therapeutic construct鈥 U.S. Patent Application PCT/US22/32324.
Significant Achievements
- 2025: Travel Grant Award for National Academies Workshop on Cancer Engineering
- 2023: Semi-Finalist for Harvard President鈥檚 Innovation Challenge Ingenuity Award
- 2022: Blavatnik Biomedical Accelerator Award
- 2022: Best Poster at PREDiCT Tumor Models Immuno Oncology Summit
- 2021: Best Poster Nomination at the Materials Research Society Fall Meeting
- 2013-15: National Science Foundation Graduate Research Fellowship
Education
- BS, University of Rochester
- PhD, Boston University
- Postdoctoral, Harvard University
Research Interests
- Bioprinting and additive manufacturing
- Biomaterials
- Cancer engineering and immunotherapy
- Engineered vascularized tissues